Effects of social reorganization on cellular immunity in male cynomolgus monkeys
Identifieur interne : 003212 ( Main/Exploration ); précédent : 003211; suivant : 003213Effects of social reorganization on cellular immunity in male cynomolgus monkeys
Auteurs : S. W. Line [États-Unis] ; J. R. Kaplan [États-Unis] ; E. R. Heise ; J. K. Hilliard ; S. Cohen ; B. S. Rabin ; S. B. ManuckSource :
- American journal of primatology [ 0275-2565 ] ; 1996.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Exposure to acute stressors has been shown to impair cellular immunity in human beings and other animal species. Comparatively little is known, however, about the effects of long-term stressors on immune function and how individual behavioral characteristics may mediate differences in immune function and clinical disease susceptibility. To determine the effects of social stress on cellular immunity and reactivation of a latent herpesvirus, 20 Herpes B virus-positive male cynomolgus monkeys were exposed to four periodic reorganizations of social group memberships over 5 months. Observations were made to categorize individuals as high or low in expression of aggressive, fearful, and affiliative behaviors. Complete blood counts, lymphocyte proliferation tests, and natural killer cell cytotoxicity assays were performed immediately before and 4 days after reorganizations. Herpesvirus-specific immunoglobulin G antibody levels were measured, and oral and conjunctival swabs were cultured for virus. Reorganization was associated with increased lymphocyte counts (P = 0.0009) and decreased lymphocyte proliferation in response to phytohemagglutinin (P < 0.005), particularly among monkeys showing high levels of fear (P = 0.0137). High-aggressive monkeys showed lower baseline natural killer cell activity (P = 0.0013) and higher lymphocyte counts (P = 0.013) than low-aggressive monkeys. Herpesvirus antibody titers decreased over time (P < 0.004) and no positive virus cultures were obtained. Measures of cellular immunity and behavior were unrelated to virus-specific antibody titers. These results suggest that repeated exposure to a social stressor alters several measures of cellular immunity, and that some of these changes may be predicted by individual differences in agonistic behavior. In contrast to human studies, the results suggest that some psychological stressors may not cause reactivation of a common herpesvirus in this species.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000333
- to stream PascalFrancis, to step Curation: 000280
- to stream PascalFrancis, to step Checkpoint: 000257
- to stream Main, to step Merge: 003223
- to stream Main, to step Curation: 003212
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Effects of social reorganization on cellular immunity in male cynomolgus monkeys</title><author><name sortKey="Line, S W" sort="Line, S W" uniqKey="Line S" first="S. W." last="Line">S. W. Line</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Comparative Medicine, Bowman Gray School of Medicine</s1><s2>Winston-Salem, North Carolina</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Kaplan, J R" sort="Kaplan, J R" uniqKey="Kaplan J" first="J. R." last="Kaplan">J. R. Kaplan</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Comparative Medicine, Bowman Gray School of Medicine</s1><s2>Winston-Salem, North Carolina</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Heise, E R" sort="Heise, E R" uniqKey="Heise E" first="E. R." last="Heise">E. R. Heise</name></author><author><name sortKey="Hilliard, J K" sort="Hilliard, J K" uniqKey="Hilliard J" first="J. K." last="Hilliard">J. K. Hilliard</name></author><author><name sortKey="Cohen, S" sort="Cohen, S" uniqKey="Cohen S" first="S." last="Cohen">S. Cohen</name></author><author><name sortKey="Rabin, B S" sort="Rabin, B S" uniqKey="Rabin B" first="B. S." last="Rabin">B. S. Rabin</name></author><author><name sortKey="Manuck, S B" sort="Manuck, S B" uniqKey="Manuck S" first="S. B." last="Manuck">S. B. Manuck</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">96-0367455</idno><date when="1996">1996</date><idno type="stanalyst">PASCAL 96-0367455 INIST</idno><idno type="RBID">Pascal:96-0367455</idno><idno type="wicri:Area/PascalFrancis/Corpus">000333</idno><idno type="wicri:Area/PascalFrancis/Curation">000280</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000257</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000257</idno><idno type="wicri:doubleKey">0275-2565:1996:Line S:effects:of:social</idno><idno type="wicri:Area/Main/Merge">003223</idno><idno type="wicri:Area/Main/Curation">003212</idno><idno type="wicri:Area/Main/Exploration">003212</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Effects of social reorganization on cellular immunity in male cynomolgus monkeys</title><author><name sortKey="Line, S W" sort="Line, S W" uniqKey="Line S" first="S. W." last="Line">S. W. Line</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Comparative Medicine, Bowman Gray School of Medicine</s1><s2>Winston-Salem, North Carolina</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Kaplan, J R" sort="Kaplan, J R" uniqKey="Kaplan J" first="J. R." last="Kaplan">J. R. Kaplan</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Comparative Medicine, Bowman Gray School of Medicine</s1><s2>Winston-Salem, North Carolina</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Heise, E R" sort="Heise, E R" uniqKey="Heise E" first="E. R." last="Heise">E. R. Heise</name></author><author><name sortKey="Hilliard, J K" sort="Hilliard, J K" uniqKey="Hilliard J" first="J. K." last="Hilliard">J. K. Hilliard</name></author><author><name sortKey="Cohen, S" sort="Cohen, S" uniqKey="Cohen S" first="S." last="Cohen">S. Cohen</name></author><author><name sortKey="Rabin, B S" sort="Rabin, B S" uniqKey="Rabin B" first="B. S." last="Rabin">B. S. Rabin</name></author><author><name sortKey="Manuck, S B" sort="Manuck, S B" uniqKey="Manuck S" first="S. B." last="Manuck">S. B. Manuck</name></author></analytic><series><title level="j" type="main">American journal of primatology</title><title level="j" type="abbreviated">Am. j. primatol.</title><idno type="ISSN">0275-2565</idno><imprint><date when="1996">1996</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">American journal of primatology</title><title level="j" type="abbreviated">Am. j. primatol.</title><idno type="ISSN">0275-2565</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term><term>Cell proliferation</term><term>Cytotoxicity</term><term>Emotion emotionality</term><term>Immune response</term><term>Lymphocyte</term><term>Macaca fascicularis</term><term>Male</term><term>Natural killer cell</term><term>Social dominance</term><term>Social organization</term><term>Stress</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Stress</term><term>Organisation sociale</term><term>Dominance sociale</term><term>Réponse immune</term><term>Lymphocyte</term><term>Multiplication cellulaire</term><term>Cellule NK</term><term>Cytotoxicité</term><term>Emotion émotivité</term><term>Mâle</term><term>Animal</term><term>Macaca fascicularis</term><term>Cercopithecidae</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Exposure to acute stressors has been shown to impair cellular immunity in human beings and other animal species. Comparatively little is known, however, about the effects of long-term stressors on immune function and how individual behavioral characteristics may mediate differences in immune function and clinical disease susceptibility. To determine the effects of social stress on cellular immunity and reactivation of a latent herpesvirus, 20 Herpes B virus-positive male cynomolgus monkeys were exposed to four periodic reorganizations of social group memberships over 5 months. Observations were made to categorize individuals as high or low in expression of aggressive, fearful, and affiliative behaviors. Complete blood counts, lymphocyte proliferation tests, and natural killer cell cytotoxicity assays were performed immediately before and 4 days after reorganizations. Herpesvirus-specific immunoglobulin G antibody levels were measured, and oral and conjunctival swabs were cultured for virus. Reorganization was associated with increased lymphocyte counts (P = 0.0009) and decreased lymphocyte proliferation in response to phytohemagglutinin (P < 0.005), particularly among monkeys showing high levels of fear (P = 0.0137). High-aggressive monkeys showed lower baseline natural killer cell activity (P = 0.0013) and higher lymphocyte counts (P = 0.013) than low-aggressive monkeys. Herpesvirus antibody titers decreased over time (P < 0.004) and no positive virus cultures were obtained. Measures of cellular immunity and behavior were unrelated to virus-specific antibody titers. These results suggest that repeated exposure to a social stressor alters several measures of cellular immunity, and that some of these changes may be predicted by individual differences in agonistic behavior. In contrast to human studies, the results suggest that some psychological stressors may not cause reactivation of a common herpesvirus in this species.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li></region></list><tree><noCountry><name sortKey="Cohen, S" sort="Cohen, S" uniqKey="Cohen S" first="S." last="Cohen">S. Cohen</name><name sortKey="Heise, E R" sort="Heise, E R" uniqKey="Heise E" first="E. R." last="Heise">E. R. Heise</name><name sortKey="Hilliard, J K" sort="Hilliard, J K" uniqKey="Hilliard J" first="J. K." last="Hilliard">J. K. Hilliard</name><name sortKey="Manuck, S B" sort="Manuck, S B" uniqKey="Manuck S" first="S. B." last="Manuck">S. B. Manuck</name><name sortKey="Rabin, B S" sort="Rabin, B S" uniqKey="Rabin B" first="B. S." last="Rabin">B. S. Rabin</name></noCountry><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Line, S W" sort="Line, S W" uniqKey="Line S" first="S. W." last="Line">S. W. Line</name></region><name sortKey="Kaplan, J R" sort="Kaplan, J R" uniqKey="Kaplan J" first="J. R." last="Kaplan">J. R. Kaplan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/StressCovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003212 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003212 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= StressCovidV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:96-0367455
|texte= Effects of social reorganization on cellular immunity in male cynomolgus monkeys
}}
| This area was generated with Dilib version V0.6.33. |  |